Background: Gliomas are the most common primary tumors of the central nervous system with an incidence of 6/100.000 and still have a bad prognosis with a median survival from six months to seven years. The therapy consists mainly of surgical resection and radiotherapy, but also chemotherapy. The impact of radiotherapy on the cognitive functioning and the health-related quality of life of patients with glioma has so far not been investigated in depth.
Objective: This study is trying to determine the impact of radiotherapy on the neurocognitive functioning and the health related quality of life of patients with glioma, who are still alive after more than five years after initial therapy, and to identify other variables which correlate with neurocognitive functioning and health related quality of life in glioma patients.
Methods: 32 patients with histologically proven grade II-IV gliomas, who received therapy before 2009 at the Department of Internal Medicine I, Medical University of Vienna, are included in this study. The patients completed three cognitive tests (HVLT, COWA and TMT) and two EORTC QLQs.
Results: No correlation between radiotherapy and cognitive status has been found. Health- related quality of life and the symptom burden of patients with glioma do not correlate with radiotherapy either.