Milk has an anti-inflammatory effect manifested by a reduction in necrotizing enterocolitis in infants. An anti-inflammatory gastrointestinal effect of milk and fermented products such as yoghurt, sour milk, buttermilk and whey in adults is suspected. Unclear is a possible anti-inflammatory effect of milk and fermenting dairy products in the oral cavity. The aim of this study was to test the anti-inflammatory effects of milk and fermented milk products on oral fibroblasts. For this purpose, gingival fibroblasts were incubated with an aqueous fraction of milk and fermented milk products with and without IL1 and TNF. The inflammatory response is determined by the expression of IL1, IL6 and IL8 by real time RT-PCR. Likewise, an immunoassay for IL6 and IL8 in the supernatant was performed. Our results showed that breast milk, cow's milk and fermented products thereof cause a significant reduction in the expression of IL1, IL-6 and IL8. For example, there has been a 72% reduction in the expression of IL1, 45% IL6 and 67% IL8 by pasteurized human milk. The data available suggest that milk and fermented products exert an anti-inflammatory effect on oral fibroblasts.