The aim of the doppler-optical coherence tomography is to visualize and quantify the retinal blood flow. A number of ocular diseases, such as diabetic retinopathy, glaucoma, age-related macular disease are in part associated with blood flow disorders. The proper knowledge of retinal blood flow could yield further information about the individual disease of a patient. In the past authors published values with high validity and reproducibility. The aim of our study was to prove this reproducibility for a prototype, built at the Center for Medical Physics and Biomedical Engineering at the Medical University of Vienna by the research group of Prof. Rainer Leitgeb. The device is a bidirectional 1050nm Swept-Source prototype. In the past two years the institute acquired patient data in cooperation with the institute of Ophthalmology and Optometry. Some of these measurements were repeated circular b-scans, focused on the optic nerve head, and allow the measurement of absolute blood flow velocities.
For this thesis, 42 vessels, of 10 eyes were manually segmented on 2x128 frames. A mean velocity of 22.4 19.75 l/min and a pulsatility index of 3.96 3.28 were observed. The variation coefficient was 88.7% and the intraclass correlation was 0.873.
Compared to other published methods, the reproducibility of our method was low. Due to an examination error the doppler signal was interfered and values with implausible high blood flow occured. We conclude that the doppler device requires more technical elaboration and studies regarding reproducibility and validity.