Bartter- and Gitelman-Syndromes are rare renal salt losing tubulopathies. The resulting electrolyte disorders, reduction of quality of life as well as the sometimes occuring cardial symptology are, in frame of a cross-sectional analysis, investigated. Transtubular potassium gradient, regarded as gold standard for potassium homeostasis, is linked to the clinical relevant endpoint, that are quality of life and cardiac arrhythmias. Eleven genetically and clinically confirmed patients participated in the study. Results confirmed reduction of quality life but uniform influence was not evident. Rather, different influential clusters could be demonstrated, suggesting more than one marker for prediciting quality of life is needed.