Drug-induced photosensitivity is an ongoing problem to modern medicine, even though many efforts in basic and clinical research have been dedicated to the topic. First, diagnosis can be difficult in the individual case, since it is heavily dependant on anamnesis and the differentiation to other forms of photodermatosis is not always evident. Second, usage of photosensitizers poses an epidemiological risk, since it has been related to an increased risk for the development of cutaneous carcinoma.
The presented pharmacoepidemiological analysis was conducted by literature and database research. A total of 387 agents was found to be related to photosensitive adverse reactions. The agents could be assigned to one of four classes, depending on the photosensitive potential and the dispersion among the population.