Go to page
 

Bibliographic Metadata

Title
A comparison of multi-echo spin-echo and triple-echo steady-state T2 mapping for in vivo evaluation of articular cartilage
AuthorJuras, Vladimir ; Bohndorf, Klaus ; Heule, Rahel ; Kronnerwetter, Claudia ; Szomolanyi, Pavol ; Hager, Benedikt ; Bieri, Oliver ; Zbyn, Stefan ; Trattnig, Siegfried
Published in
European Radiology, New York, 2016, Vol. 26, Issue 6, page 1905-1912
PublishedNew York : Springer, 2016
LanguageEnglish
Document typeJournal Article
Keywords (EN)t2 mapping / cartilage / cpmg / tess / osteoarthritis / repair tissue / biomechanical properties / knee osteoarthritis / relaxation-times / quantitative mri / differentiation / degeneration / relaxometry / sequence
Project-/ReportnumberP 25246-B24
ISSN0938-7994
URNurn:nbn:at:at-ubmuw:3-1312 Persistent Identifier (URN)
DOI10.1007/s00330-015-3979-6 
Restriction-Information
 The work is publicly available
Files
A comparison of multi-echo spin-echo and triple-echo steady-state T2 mapping for in vivo evaluation of articular cartilage [0.71 mb]
Links
Reference
Classification
Abstract (English)

To assess the clinical relevance of T-2 relaxation times, measured by 3D triple-echo steady-state (3D-TESS), in knee articular cartilage compared to conventional multi-echo spin-echo T-2-mapping. Thirteen volunteers and ten patients with focal cartilage lesions were included in this prospective study. All subjects underwent 3-Tesla MRI consisting of a multi-echo multi-slice spin-echo sequence (CPMG) as a reference method for T-2 mapping, and 3D TESS with the same geometry settings, but variable acquisition times: standard (TESSs 4:35min) and quick (TESSq 2:05min). T-2 values were compared in six different regions in the femoral and tibial cartilage using a Wilcoxon signed ranks test and the Pearson correlation coefficient (r). The local ethics committee approved this study, and all participants gave written informed consent. The mean quantitative T-2 values measured by CPMG (mean: 46 +/- 9ms) in volunteers were significantly higher compared to those measured with TESS (mean: 31 +/- 5ms) in all regions. Both methods performed similarly in patients, but CPMG provided a slightly higher difference between lesions and native cartilage (CPMG: 90ms -> 61ms [31%],p=0.0125;TESS 32ms -> 24ms [24%],p=0.0839). 3D-TESS provides results similar to those of a conventional multi-echo spin-echo sequence with many benefits, such as shortening of total acquisition time and insensitivity to B-1 and B-0 changes. aEuro cent 3D-TESS T (2) mapping provides clinically comparable results to CPMG in shorter scan-time. aEuro cent Clinical and investigational studies may benefit from high temporal resolution of 3D-TESS. aEuro cent 3D-TESS T (2) values are able to differentiate between healthy and damaged cartilage.

Stats
The PDF-Document has been downloaded 6 times.
License
CC-BY-NC-License (4.0)Creative Commons Attribution - NonCommercial 4.0 International License