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Title
Monitoring the epitope recognition profiles of IgE, IgG(1), and IgG(4) during birch pollen immunotherapy
AuthorGepp, Barbara ; Lengger, Nina ; Moebs, Christian ; Pfuetzner, Wolfgang ; Radauer, Christian ; Bohle, Barbara ; Breiteneder, Heimo
Published in
Journal of Allergy and Clinical Immunology, New York, 2016, Vol. 137, Issue 5, page 1600-1603
PublishedNew York : Elsevier, 2016
LanguageEnglish
Document typeJournal Article
Keywords (EN)bet v 1 / oral immunotherapy / allergen / responses
Project-/ReportnumberF 4608-B28
ISSN0091-6749
URNurn:nbn:at:at-ubmuw:3-1712 Persistent Identifier (URN)
DOI10.1016/j.jaci.2015.10.022 
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 The work is publicly available
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Monitoring the epitope recognition profiles of IgE, IgG(1), and IgG(4) during birch pollen immunotherapy [0.94 mb]
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Abstract (English)

It is well established that allergen-specific IgG antibodies induced during allergen-specific immunotherapy (AIT) can block the IgE-mediated cascade of allergic inflammation.1 Although this role of IgG has been intensively studied, little is known about the epitope diversities of immunoglobulin subclasses induced during AIT. Thus far, analyses of IgG4-binding patterns to major cow's milk2 and peanut3 allergens during oral AIT revealed discrepant results. The overall diversity of IgG4 specific for cow's milk allergens changed little,2 whereas the IgG4 repertoire specific for peanut allergens was broadly expanded in a polyclonal fashion, including de novogenerated specificities different from IgE.

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CC-BY-NC-ND-License (4.0)Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License