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Titel
Mediator and TREX-2: Emerging links between transcription initiation and mRNA export
Verfasser / VerfasserinKoehler, Alwin ; Schubert, Tobias
Erschienen in
Nucleus, Philadelphia, 2016, Jg. 7, H. 2, S. 126-131
ErschienenPhiladelphia : Taylor & Francis, 2016
SpracheEnglisch
DokumenttypAufsatz in einer Zeitschrift
Schlagwörter (EN)mediator / nuclear pore complex / transcription coupled mrna export / trex-2 / polymerase-ii ctd / nuclear-pores / structural-characterization / gene-expression / pol ii / complex / yeast / phosphorylation / localization / dissociation
Projekt-/ReportnummerY 557-B11
ISSN1949-1034
URNurn:nbn:at:at-ubmuw:3-1681 Persistent Identifier (URN)
DOI10.1080/19491034.2016.1169352 
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Mediator and TREX-2: Emerging links between transcription initiation and mRNA export [1.1 mb]
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Zusammenfassung (Englisch)

Nuclear pore proteins interact dynamically with chromatin to regulate gene activities. A key question is how nucleoporin interactions mechanistically alter a gene's intranuclear position and transcriptional output. We reported recently on a direct interaction between the nuclear pore-associated TREX-2 complex and promoter-bound Mediator. This highlights how nuclear-pore associated adaptors gain regulatory access to the core transcription machinery. In this Extra View, we discuss an additional implication that arises from our work and the recent literature: how promoter elements may regulate mRNA metabolism beyond transcription initiation.

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CC-BY-Lizenz (4.0)Creative Commons Namensnennung 4.0 International Lizenz