Go to page
 

Bibliographic Metadata

Title
Mediator and TREX-2: Emerging links between transcription initiation and mRNA export
AuthorKoehler, Alwin ; Schubert, Tobias
Published in
Nucleus, Philadelphia, 2016, Vol. 7, Issue 2, page 126-131
PublishedPhiladelphia : Taylor & Francis, 2016
LanguageEnglish
Document typeJournal Article
Keywords (EN)mediator / nuclear pore complex / transcription coupled mrna export / trex-2 / polymerase-ii ctd / nuclear-pores / structural-characterization / gene-expression / pol ii / complex / yeast / phosphorylation / localization / dissociation
Project-/ReportnumberY 557-B11
ISSN1949-1034
URNurn:nbn:at:at-ubmuw:3-1681 Persistent Identifier (URN)
DOI10.1080/19491034.2016.1169352 
Restriction-Information
 The work is publicly available
Files
Mediator and TREX-2: Emerging links between transcription initiation and mRNA export [1.1 mb]
Links
Reference
Classification
Abstract (English)

Nuclear pore proteins interact dynamically with chromatin to regulate gene activities. A key question is how nucleoporin interactions mechanistically alter a gene's intranuclear position and transcriptional output. We reported recently on a direct interaction between the nuclear pore-associated TREX-2 complex and promoter-bound Mediator. This highlights how nuclear-pore associated adaptors gain regulatory access to the core transcription machinery. In this Extra View, we discuss an additional implication that arises from our work and the recent literature: how promoter elements may regulate mRNA metabolism beyond transcription initiation.

Stats
The PDF-Document has been downloaded 3 times.
License
CC-BY-License (4.0)Creative Commons Attribution 4.0 International License