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Title
Recombinant Mal d 1 facilitates sublingual challenge tests of birch pollen-allergic patients with apple allergy
AuthorBohle, B. ; Wolkersdorfer, M. ; Kopp, S. ; Kinaciyan, T. ; Faustmann, S. ; Nagl, B.
Published in
Allergy: European Journal of Allergy and Clinical Immunology, Hoboken, 2016, Vol. 71, Issue 2, page 272-274
PublishedHoboken : Wiley-Blackwell, 2016
LanguageEnglish
Document typeJournal Article
Keywords (EN)bet v 1 / birch pollen-related food allergy / mal d 1 / recombinant allergens / eaaci food allergy / immune-response / immunotherapy
Project-/ReportnumberF 4610-B28
ISSN0105-4538
URNurn:nbn:at:at-ubmuw:3-1858 Persistent Identifier (URN)
DOI10.1111/all.12781 
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 The work is publicly available
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Recombinant Mal d 1 facilitates sublingual challenge tests of birch pollen-allergic patients with apple allergy [0.17 mb]
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Abstract (English)

It is still unclear whether allergen-specific immunotherapy (AIT) with birch pollen improves birch pollen-related food allergy. One reason for this may be the lack of standardized tests to assess clinical reactions to birch pollen-related foods, for example apple. We tested the applicability of recombinant (r) Mal d 1, the Bet v 1-homolog in apple, for oral challenge tests. Increasing concentrations of rMal d 1 in 0.9% NaCl were sublingually administered to 72 birch pollen-allergic patients with apple allergy. The dose of 1.6 g induced oral allergy syndromes in 26.4%, 3.2 g in 15.3%, 6.3 g in 27.8%, 12.5 g in 8.3%, 25 g in 11.1%, and 50 g in 4.2% of the patients. No severe reactions occurred. None of the patients reacted to 0.9% NaCl alone. Sublingual administration of 50 g of rMal d 1 induced no reactions in three nonallergic individuals. Our approach allows straight forward, dose-defined sublingual challenge tests in a high number of birch pollen-allergic patients that inter alia can be applied to evaluate the therapeutic efficacy of birch pollen AIT on birch pollen-related food allergy.

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CC-BY-License (4.0)Creative Commons Attribution 4.0 International License