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Title
Factors Determining Flicker-Induced Retinal Vasodilation in Healthy Subjects
AuthorSchmetterer, Leopold ; Garhoefer, Gerhar ; Werkmeister, Rene M. ; Schmidlj, Doreen ; Rauch, Alexandra ; Sapeta, Sabina ; Aschinger, Gerold C. ; Witkowskaj, Katarzyna J. ; Sharifizad, Mozhgan
Published in
Investigative Ophthalmology and Visual Science, Rockville, 2016, Vol. 57, Issue 7, page 3306-3312
PublishedRockville : ARVO -The Association for Research in Vision and Ophthalmology, 2016
LanguageEnglish
Document typeJournal Article
Keywords (EN)flicker stimulation / neurovascular coupling / retinal vessels / optic-nerve head / diffuse luminance flicker / coronary-artery-disease / blood-flow / nitric-oxide / diabetic-retinopathy / vessel diameters / endothelial dysfunction / functional hyperemia / ocular hypertension
Project-/ReportnumberKLI 250
ISSN0146-0404
URNurn:nbn:at:at-ubmuw:3-1517 Persistent Identifier (URN)
DOI10.1167/iovs.16-19261 
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Abstract (English)

PURPOSE. The purpose of this study was to analyze factors determining retinal arterial and venous responses to stimulation with diffuse luminance flicker in healthy subjects. METHODS. We retrospectively analyzed results obtained in 374 healthy subjects who had previously participated in clinical studies in our department. A total of 153 subjects underwent a protocol in which flicker stimulation was delivered through the fundus camera at 8 Hz (protocol 1), separating measurement and stimulation light depending on the wavelength, and 221 subjects underwent a protocol in which diffuse luminance flicker was delivered at 12.5 Hz with high modulation depth (protocol 2). We investigated whether sex, systemic blood pressure, baseline vessel size, blood plasma concentration of fasting glucose and hematocrit, and serum concentration of cholesterol, triglycerides, creatinine and Creactive protein influenced the retinal vascular response to flicker stimulation RESULTS. Flicker responses in arteries and veins were more pronounced in protocol 2 than in protocol 1 (P < 0.001, each). In both of the protocols the vascular response to stimulation with diffuse luminance flicker was larger in smaller vessels (P between 0.001 and 0.016). In protocol 2 the retinal arterial flicker response was negatively associated with cholesterol serum levels (P = 0.033); in protocol 1, only a tendency toward this effect was observed (P 0.056). CONCLUSIONS. The present analysis indicates that retinal arterial and venous responses to stimulation with diffuse luminance flicker depend on the way the stimulation is delivered through the ftndus camera. In addition, the flicker response varied with vessel size, that is, the smaller the vessel width, the larger the flicker response. Finally, our data indicate that, even within the normal range, higher cholesterol serum levels are associated with lower hyperemic flicker responses.

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CC-BY-NC-ND-License (4.0)Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License