Go to page
 

Bibliographic Metadata

Title
Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks
AuthorBock, Christoph ; Oscier, David ; Farlik, Matthias ; Davis, Zadie ; Walewska, Renata ; Strefford, Jonathan C. ; Schmidl, Christian ; Rendeiro, Andre F.
Published in
Nature Communications, London, 2016, Vol. 7, page 11938
PublishedLondon : Nature Publishing Group, 2016
LanguageEnglish
Document typeJournal Article
Keywords (EN)b-cell receptor / rna-seq data / clinical-significance / factor-binding / chip-seq / expression / mutations / genome / genes
Project-/ReportnumberI 1626-B22
ISSN2041-1723
URNurn:nbn:at:at-ubmuw:3-16 Persistent Identifier (URN)
DOI10.1038/ncomms11938 
Restriction-Information
 The work is publicly available
Files
Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks [2.53 mb]
Links
Reference
Classification
Abstract (English)

Chronic lymphocytic leukaemia (CLL) is characterized by substantial clinical heterogeneity, despite relatively few genetic alterations. To provide a basis for studying epigenome deregulation in CLL, here we present genome-wide chromatin accessibility maps for 88 CLL samples from 55 patients measured by the ATAC-seq assay. We also performed ChIPmentation and RNA-seq profiling for ten representative samples. Based on the resulting data set, we devised and applied a bioinformatic method that links chromatin profiles to clinical annotations. Our analysis identified sample-specific variation on top of a shared core of CLL regulatory regions. IGHV mutation status-which distinguishes the two major subtypes of CLL-was accurately predicted by the chromatin profiles and gene regulatory networks inferred for IGHV-mutated versus IGHV-unmutated samples identified characteristic differences between these two disease subtypes. In summary, we discovered widespread heterogeneity in the chromatin landscape of CLL, established a community resource for studying epigenome deregulation in leukaemia and demonstrated the feasibility of large-scale chromatin accessibility mapping in cancer cohorts and clinical research.

Stats
The PDF-Document has been downloaded 2 times.
License
CC-BY-License (4.0)Creative Commons Attribution 4.0 International License