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Title
Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report
AuthorBrodowicz, Thomas ; Hamacher, Rainer ; Schur, Sophie
Published in
Case Reports in Oncology, Basel, 2016, Vol. 9, Issue 2, page 363-367
PublishedBasel : Karger, 2016
LanguageEnglish
Document typeJournal Article
Keywords (EN)Cardiac sarcoma / Angiosarcoma / Soft tissue sarcoma / Right atrium / Pazopanib
ISSN1662-6575
URNurn:nbn:at:at-ubmuw:3-72 Persistent Identifier (URN)
DOI10.1159/000447088 
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 The work is publicly available
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Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report [0.54 mb]
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Abstract (English)

Primary heart tumors are an extremely rare oncological entity with primary cardiac sarcomas usually representing 20% of all primary cardiac tumorous lesions [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925932; Orlandi et al.: J Thorac Oncol 2010;5: 14831489]. Angiosarcoma is the most prevalent histology and despite a multidisciplinary approach tends to have a dismal prognosis [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925932; Fury et al.: Cancer J 2005;11: 241247]. Based on the prevailing literature, we report a 48-year-old woman diagnosed with primary metastatic cardiac angiosarcoma who showed a severe hypersensitivity reaction to conventional chemotherapy with taxanes but an excellent response to treatment with the multitargeted receptor tyrosine kinase inhibitor pazopanib.

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CC-BY-NC-License (4.0)Creative Commons Attribution - NonCommercial 4.0 International License