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Titel
Visualizing the quantile survival time difference curve
Verfasser / VerfasserinMittlboeck, Martina ; Heinzl, Harald
Erschienen in
Journal of Evaluation in Clinical Practice, 2018, Jg. 24, H. 4, S. 708-712
ErschienenWiley-Blackwell, 2018
SpracheEnglisch
DokumenttypAufsatz in einer Zeitschrift
Schlagwörter (EN)bootstrap samples / confidence bands / exploratory data analysis / KaplanMeier curves / SAS macro
URNurn:nbn:at:at-ubmuw:3-174 Persistent Identifier (URN)
DOI10.1111/jep.12948 
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 Das Werk ist frei verfügbar
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Visualizing the quantile survival time difference curve [0.35 mb]
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Zusammenfassung (Englisch)

The difference between the pth quantiles of 2 survival functions can be used to compare patients' survival between 2 therapies. Setting p = 0.5 yields the median survival time difference. Varying p between 0 and 1 defines the quantile survival time difference curve which can be straightforwardly estimated by the horizontal differences between 2 KaplanMeier curves. The estimate's variability can be visualized by adding either a bundle of resampled bootstrap step functions or, alternatively, approximate bootstrap confidence bands. The userfriendly SAS software macro %kmdiff enables the straightforward application of this exploratory graphical approach. The macro is described, and its application is exemplified with breast cancer data. The advantages and limitations of the approach are discussed.

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CC-BY-Lizenz (4.0)Creative Commons Namensnennung 4.0 International Lizenz