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Titel
Optic nerve head morphology in primary open-angle glaucoma and nonarteritic anterior ischemic optic neuropathy measured with spectral domain optical coherence tomography
Verfasser / VerfasserinVass, Clemens ; Resch, Hemma ; Mitsch, Christoph ; Pereira, Ivania ; Schwarzhans, Florian ; Wasserman, Lorenz ; Hommer, Anton ; Reitner, Andreas
Erschienen in
Acta Ophthalmologica, 2018, Jg. 96, H. 8, S. e1018-e1024
ErschienenWiley-Blackwell, 2018
SpracheEnglisch
DokumenttypAufsatz in einer Zeitschrift
Schlagwörter (EN)Bruch's membrane openingminimum rim width / nonarteritic anterior ischaemic optic neuropathy / primary openangle glaucoma / retinal nerve fibre layer / spectral domain optical coherence tomography
URNurn:nbn:at:at-ubmuw:3-201 Persistent Identifier (URN)
DOI10.1111/aos.13804 
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Optic nerve head morphology in primary open-angle glaucoma and nonarteritic anterior ischemic optic neuropathy measured with spectral domain optical coherence tomography [0.41 mb]
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Zusammenfassung (Englisch)

Purpose

Optic nerve head (ONH) parameters as well as circumpapillary retinal nerve fibre layer (RNFL) thickness values measured with two different spectral domain optical coherence tomography (SDOCT) machines (Spectralis® and Cirrus® OCT) have been compared between two patient groups, primary openangle glaucoma (POAG), nonarteritic anterior ischaemic optic neuropathy (NAION) and healthy controls. A comparison of the performance of the two OCT machines was made.

Methods

Twenty healthy controls, 20 POAG and 20 NAION patients with comparable visual field defects were included. Comparison between groups was made using anova and post hoc ttests. To evaluate the diagnostic power of OCT to differentiate POAG from NAION, a stepwise linear regression analysis of the rimRNFL correlation with adjusting covariates (optic disc area and age) was performed. Based on the regression formula, the area under the receiver operator characteristic (AUROC) was calculated.

Results

Both glaucoma and NAION patients showed significantly smaller global RNFL thickness values compared to healthy subjects in ttests (p < 0.001), while only patients with glaucoma showed significantly smaller global ONH parameters for both devices compared to healthy subjects (p < 0.001). Correlation between global ONH parameters was highly statistically significant (r = 0.93), whereas in ttest a statistically significant difference between the two machines was detected (p < 0.001). Area under the receiver operator characteristic revealed a similarly good discrimination between glaucoma and NAION for Spectralis® (0.980) and Cirrus® OCT (0.945).

Conclusion

NAION patients have similar RNFL thickness values as do glaucomatous eyes, whereas ONH parameters in NAION eyes were similar to those seen in healthy controls. This difference might help discriminating between these two different disease conditions in a chronic disease stadium, and in this regard, none of the two OCT machines performed better.

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