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Title
Age dependent effect of targeted temperature management on outcome after cardiac arrest
AuthorTestori, Christoph ; Wallmüller, Christian ; Spiel, Alexander ; Sterz, Fritz ; Schober, Andreas ; Hubner, Pia ; Stratil, Peter
Published in
European Journal of Clinical Investigation, 2018, Vol. 48, Issue 12, e13026
PublishedWiley-Blackwell, 2018
LanguageEnglish
Document typeJournal Article
Keywords (EN)cardiopulmonary resuscitation / induced hypothermia / prognosis / resuscitation / survival
URNurn:nbn:at:at-ubmuw:3-375 Persistent Identifier (URN)
DOI10.1111/eci.13026 
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 The work is publicly available
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Age dependent effect of targeted temperature management on outcome after cardiac arrest [0.25 mb]
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Abstract (German)

Background

In elder patients after outofhospital cardiac arrest, diminished neurologic function as well as reduced neuronal plasticity may cause a low response to targeted temperature management (TTM). Therefore, we investigated the association between TTM (3234C) and neurologic outcome in cardiac arrest survivors with respect to age.

Material and Methods

This retrospective cohort study included patients 18 years of age or older suffering a witnessed outofhospital cardiac arrest with presumed cardiac cause, which remained comatose after return of spontaneous circulation. Patients were a priori split by age into four groups (<50 years (n = 496); 5064 years (n = 714); 6574 years (n = 395); >75 years (n = 280)). Subsequently, within these groups, patients receiving TTM were compared to those not treated with TTM.

Results

Out of 1885 patients, 921 received TTM for 24 hours. TTM was significantly associated with good neurologic outcome in patients <65 years of age whereas showing no effect in elders (6574 years: OR: 1.49 (95% CI: 0.902.47); > 75 years: OR 1.44 (95% CI 0.792.34)).

Conclusion

In our cohort, it seems that TTM might not be able to achieve the same benefit for neurologic outcome in all age groups. Although the results of this study should be interpreted with caution, TTM was associated with improved neurologic outcome only in younger individuals, patients with 65 years of age or older did not benefit from this treatment.

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CC-BY-NC-License (4.0)Creative Commons Attribution - NonCommercial 4.0 International License