Zur Seitenansicht
 

Titelaufnahme

Titel
Molecular allergen profiling in horses by microarray reveals Fag e 2 from buckwheat as a frequent sensitizer
Verfasser / VerfasserinJensen-Jarolim, Erika ; Einhorn, L. ; Hofstetter, G. ; Brandt, S. ; Hainisch, E. K. ; Fukuda, I. ; Kusano, K. ; Scheynius, A. ; Mittermann, I. ; Resch-Marat, Y. ; Vrtala, S. ; Valenta, R. ; Marti, E. ; Rhyner, C. ; Crameri, R. ; Satoh, R. ; Teshima, R. ; Tanaka, A. ; Sato, H. ; Pali-Schöll, I.
Erschienen in
Allergy, 2018, Jg. 73, H. 7, S. 1436-1446
ErschienenWiley-Blackwell, 2018
SpracheEnglisch
DokumenttypAufsatz in einer Zeitschrift
Schlagwörter (EN)allergen / microarray / componentresolved diagnosis / horse / IgE / ISAC / molecular
URNurn:nbn:at:at-ubmuw:3-436 Persistent Identifier (URN)
DOI10.1111/all.13417 
Zugriffsbeschränkung
 Das Werk ist frei verfügbar
Dateien
Molecular allergen profiling in horses by microarray reveals Fag e 2 from buckwheat as a frequent sensitizer [1.77 mb]
Links
Nachweis
Klassifikation
Zusammenfassung (Englisch)

Background

Companion animals are also affected by IgEmediated allergies, but the eliciting molecules are largely unknown. We aimed at refining an allergen microarray to explore sensitization in horses and compare it to the human IgE reactivity profiles.

Methods

Customdesigned allergen microarray was produced on the basis of the ImmunoCAP ISAC technology containing 131 allergens. Sera from 51 horses derived from Europe or Japan were tested for specific IgE reactivity. The included horse patients were diagnosed for eczema due to insect bite hypersensitivity, chronic coughing, recurrent airway obstruction and urticaria or were clinically asymptomatic.

Results

Horses showed individual IgEbinding patterns irrespective of their health status, indicating sensitization. In contrast to European and Japanese human sensitization patterns, frequently recognized allergens were Aln g 1 from alder and Cyn d 1 from Bermuda grass, likely due to specific respiratory exposure around paddocks and near the ground. The most prevalent allergen for 72.5% of the tested horses (37/51) was the 2Salbumin Fag e 2 from buckwheat, which recently gained importance not only in human but also in horse diet.

Conclusion

In line with the One Health concept, covering human health, animal health and environmental health, allergen microarrays provide novel information on the allergen sensitization patterns of the companion animals around us, which may form a basis for allergenspecific preventive and therapeutic concepts.

Statistik
Das PDF-Dokument wurde 2 mal heruntergeladen.
Lizenz
CC-BY-Lizenz (4.0)Creative Commons Namensnennung 4.0 International Lizenz