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Morphology of nuclear transcription
Verfasser / VerfasserinSchöfer, Christian ; Weipoltshammer, Klara
Erschienen in
Histochemistry and Cell Biology, 2016, Jg. 145, H. 4, S. 343-358
ErschienenSpringer, 2016
DokumenttypAufsatz in einer Zeitschrift
Schlagwörter (EN)Nuclear architecture / Nucleoli / Transcription factory / Chromatin / Loop formation / Epigenetic gene regulation
URNurn:nbn:at:at-ubmuw:3-561 Persistent Identifier (URN)
 Das Werk ist frei verfügbar
Morphology of nuclear transcription [1.47 mb]
Zusammenfassung (Englisch)

Gene expression control is a fundamental determinant of cellular life with transcription being the most important step. The spatial nuclear arrangement of the transcription process driven by RNA polymerases II and III is nonrandomly organized in foci, which is believed to add another regulatory layer on gene expression control. RNA polymerase I transcription takes place within a specialized organelle, the nucleolus. Transcription of ribosomal RNA directly responds to metabolic requirements, which in turn is reflected in the architecture of nucleoli. It differs from that of the other polymerases with respect to the gene template organization, transcription rate, and epigenetic expression control, whereas other features are shared like the formation of DNA loops bringing genes and components of the transcription machinery in close proximity. In recent years, significant advances have been made in the understanding of the structural prerequisites of nuclear transcription, of the arrangement in the nuclear volume, and of the dynamics of these entities. Here, we compare ribosomal RNA and mRNA transcription side by side and review the current understanding focusing on structural aspects of transcription foci, of their constituents, and of the dynamical behavior of these components with respect to foci formation, disassembly, and cell cycle.

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