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Titel
Target site pharmacokinetics of doxycycline for rosacea in healthy volunteers is independent of food-effect
Verfasser / VerfasserinMatzneller, Peter ; Pal, Arindam ; Gautam, Anirudh ; Österreicher, Zoe ; Wulkersdorfer, Beatrix ; Reiter, Birgit ; Stimpfl, Thomas ; Zeitlinger, Markus
Erschienen in
British Journal of Clinical Pharmacology, 2018, Jg. 84, H. ue, S. 2625-2633
ErschienenWiley-Blackwell, 2018
SpracheEnglisch
DokumenttypAufsatz in einer Zeitschrift
Schlagwörter (EN)antibiotics / dermatology / food/herbal drug interactions / inflammation / pharmacokinetics
URNurn:nbn:at:at-ubmuw:3-668 Persistent Identifier (URN)
DOI10.1111/bcp.13721 
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 Das Werk ist frei verfügbar
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Target site pharmacokinetics of doxycycline for rosacea in healthy volunteers is independent of food-effect [0.55 mb]
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Zusammenfassung (Englisch)

Aims

Doxycycline (DFD09) oral capsules 40 mg are approved for the treatment of inflammatory lesions of rosacea. Unlike the foodinduced lowering of doxycycline's peak plasma concentration (Cmax), its exposure under fed conditions in the skin, the drug's target site for rosacea, is unknown. The present study explored the effect of food on the dermal pharmacokinetics of doxycycline.

Methods

The pharmacokinetics of doxycycline in the dermal interstitial fluid (dISF) and plasma of healthy volunteers were assessed in parallel groups under fed (n = 6) and fasting (n = 6) conditions during a 14day oncedaily treatment course with doxycycline oral capsules 40 mg (DFD09). Sampling of dISF and plasma was performed on days 1, 10 (fasting group dISF only) and 14.

Results

Twelve subjects were randomized, and 11 analysed. No causally drugrelated adverse events occurred. Dermal doxycycline exposures (Cmax and area under the curve) under the fed state were about 30% lower than under the fasting state at day 1 but were similar at steady state. In analogy to skin, plasma exposure showed no betweengroup difference at steady state. Accumulation ratios were higher in the skin than in plasma. Correcting for plasma protein binding (90%), dermal doxycycline exposure was approximately threefold higher than unbound plasma exposure.

Conclusions

At steady state, doxycycline concentrations in the skin of fed and fasting healthy volunteers were comparable. Doxycycline's efficacy in rosacea is possibly due to considerable dermal accumulation of unbound doxycycline and is independent of the effect of food.

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CC-BY-NC-Lizenz (4.0)Creative Commons Namensnennung - Nicht kommerziell 4.0 International Lizenz