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Title
Flotillin-1 interacts with the serotonin transporter and modulates chronic corticosterone response
AuthorPollak, Daniela ; Reisinger, S.N. ; Kong, E. ; Molz, B. ; Humberg, T. ; Sideromenos, S. ; Cicvaric, A. ; Steinkellner, T. ; Yang, J.-W. ; Cabatic, M. ; Monje, F.J. ; Sitte, H.H. ; Nichols, B.J.
Published in
Genes, Brain and Behavior, 2019, Vol. 18, Issue 2, e12482
PublishedWiley-Blackwell, 2019
LanguageEnglish
Document typeJournal Article
Keywords (EN)animal model / chronic corticosterone / depression / Flotillin1 / serotonin transporter / SERT
URNurn:nbn:at:at-ubmuw:3-805 Persistent Identifier (URN)
DOI10.1111/gbb.12482 
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Abstract (English)

Aberrant serotonergic neurotransmission in the brain is considered at the core of the pathophysiological mechanisms involved in neuropsychiatric disorders. Gene by environment interactions contribute to the development of depression and involve modulation of the availability and functional activity of the serotonin transporter (SERT). Using behavioral and in vivo electrophysiological approaches together with biochemical, molecularbiological and molecular imaging tools we establish Flotillin1 (Flot1) as a novel protein interacting with SERT and demonstrate its involvement in the response to chronic corticosterone (CORT) treatment. We show that genetic Flot1 depletion augments chronic CORTinduced behavioral despair and describe concomitant alterations in the expression of SERT, activity of serotonergic neurons and alterations of the glucocorticoid receptor transport machinery. Hence, we propose a role for Flot1 as modulatory factor for the depressogenic consequences of chronic CORT exposure and suggest Flotillin1dependent regulation of SERT expression and activity of serotonergic neurotransmission at the core of the molecular mechanisms involved.

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CC-BY-License (4.0)Creative Commons Attribution 4.0 International License