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Dura mater is a potential source of A seeds
Verfasser / VerfasserinKovacs, Gabor G. ; Lutz, Mirjam I. ; Ricken, Gerda ; Ströbel, Thomas ; Höftberger, Romana ; Preusser, Matthias ; Regelsberger, Günther ; Hönigschnabl, Selma ; Reiner, Angelika ; Fischer, Peter ; Budka, Herbert ; Hainfellner, Johannes A.
Erschienen in
Acta Neuropathologica, 2016, Jg. 131, H. 6, S. 911-923
ErschienenSpringer, 2016
SpracheEnglisch
DokumenttypAufsatz in einer Zeitschrift
Schlagwörter (EN)Alzheimer disease / Amyloid- / Dura mater / Iatrogenic Creutzfeldt-Jakob disease / Prion / Propagon
URNurn:nbn:at:at-ubmuw:3-1203 Persistent Identifier (URN)
DOI10.1007/s00401-016-1565-x 
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Dura mater is a potential source of A seeds [4.63 mb]
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Deposition of amyloid- (A) in the brain parenchyma and vessels is one of the hallmarks of Alzheimer disease (AD). Recent observations of A deposition in iatrogenic Creutzfeldt-Jakob disease (iCJD) after dural grafting or treatment with pituitary extracts raised concerns whether A is capable of transmitting disease as seen in prion diseases by the disease-associated prion protein. To address this issue, we re-sampled and re-evaluated archival material, including the grafted dura mater of two cases with iCJD (28 and 33-years-old) without mutations in the APP, PSEN1 and PSEN2 genes, and carrying 3/3 alleles of the APOE gene. In addition, we evaluated 84 dura mater samples obtained at autopsy (mean age 84.9 0.3) in the community-based VITA study for the presence of A deposition. We show that the dura mater may harbor A deposits (13 %) in the form of cerebral amyloid angiopathy or amorphous aggregates. In both iCJD cases, the grafted dura mater had accumulated A. The morphology and distribution pattern of cerebral A deposition together with the lack of tau pathology distinguishes the A proteinopathy in iCJD from AD, from that seen in young individuals without cognitive decline carrying one or two APOE4 alleles, and from that related to traumatic brain injury. Our novel findings of A deposits in the dura mater, including the grafted dura, and the distinct cerebral A distribution in iCJD support the seeding properties of A. However, in contrast to prion diseases, our study suggests that such A seeding is unable to reproduce the full clinicopathological phenotype of AD.

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CC-BY-Lizenz (4.0)Creative Commons Namensnennung 4.0 International Lizenz