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Endoplasmosis and exoplasmosis : the evolutionary principles underlying endocytosis, exocytosis, and vesicular transport
AuthorSchmid, Johannes A.
Published in
Wiener Medizinische Wochenschrift, 2016, Vol. 166, Issue 7-8, page 236-241
PublishedSpringer, 2016
Document typeJournal Article
Keywords (EN)Lipid Bilayers / Membrane Fusion / Eukaryotic Cells / Extracellular Space / Membranes / Endocytosis / Exocytosis
URNurn:nbn:at:at-ubmuw:3-1267 Persistent Identifier (URN)
 The work is publicly available
Endoplasmosis and exoplasmosis [1.18 mb]
Abstract (English)

Eukaryotic cells are characterized by a multicompartmental structure with a variety of organelles. Vesicular transport between these compartments requires membrane fusion events. Based on a membrane topology view, we conclude that there are two basic mechanisms of membrane fusion, namely where the membranes first come in contact with the cis-side (the plasmatic phase of the lipid bilayer) or with the trans-side (the extra-plasmatic face). We propose to designate trans-membrane fusion processes as “endoplasmosis” as they lead to uptake of a compartment into the plasmatic phase. Vice versa we suggest the term “exoplasmosis” (as already suggested in a 1964 publication) for cis-membrane fusion events, where the interior of a vesicle is released to an extraplasmatic environment (the extracellular space or the lumen of a compartment). This concept is supported by the fact that all cis- and all trans-membrane fusions, respectively, exhibit noticeable similarities implying that they evolved from two functionally different mechanisms.

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