Zur Seitenansicht
 

Titelaufnahme

Titel
Upregulated TNF Expression 1 Year After Bariatric Surgery Reflects a Cachexia-Like State in Subcutaneous Adipose Tissue
Verfasser / VerfasserinStulnig, Thomas Michael ; Jürets, Alexander ; Itariu, Bianca Karla ; Keindl, Magdalena ; Prager, Gerhard ; Langer, Felix ; Grablowitz, Viktor ; Zeyda, Maximilian
Erschienen in
Obesity Surgery, 2017, Jg. 27, H. 6, S. 1514-1523
ErschienenSpringer, 2017
SpracheEnglisch
DokumenttypAufsatz in einer Zeitschrift
Schlagwörter (EN)Tumor necrosis factor / Bariatric surgery / Subcutaneous adipose tissue / Gene expression / Weight loss
URNurn:nbn:at:at-ubmuw:3-3342 Persistent Identifier (URN)
DOI10.1007/s11695-016-2477-5 
Zugriffsbeschränkung
 Das Werk ist frei verfügbar
Dateien
Upregulated TNF Expression 1 Year After Bariatric Surgery Reflects a Cachexia-Like State in Subcutaneous Adipose Tissue [0.58 mb]
Links
Nachweis
Klassifikation
Zusammenfassung (Englisch)

Background

Adipose tissue dysfunction contributes to obesity-associated chronic diseases. In the first year after bariatric surgery, obese patients significantly improve their metabolic status upon losing weight. We aimed to investigate whether changes in subcutaneous adipose tissue gene expression reflect a restoration of a healthy lean phenotype after bariatric surgery.

Methods

Thirty-one severely obese patients (BMI 40 kg/m2) were examined before and after surgery. subcutaneous adipose tissue (SAT) was collected during and 1 year after bariatric surgery. SAT from 20 matched lean and overweight patients (BMI < 30 kg/m2) was collected during elective abdominal surgery. Baseline characteristics and SAT gene expression relevant to glucose and lipid metabolism, inflammation, and apoptosis were analyzed.

Results

After surgery, mean BMI decreased from 46.1 6.3 to 31.1 5.7 kg/m2 and homeostasis model assessment of insulin resistance from 5.4 5.3 to 0.8 0.8. SAT expression of most analyzed inflammatory cytokines, growth factors, and metabolic and cell surface markers was greatly downregulated even compared to the lean cohort. In contrast, gene expression of TNF and CASP3 was significantly upregulated. Elastic net regression analysis showed that fasting glucose levels and CASP3 predicted increased TNF expression in the post-obese group.

Conclusions

Gene expression patterns in SAT 1 year after bariatric surgery point to a reduced inflammation. The unexpected high TNF expression in SAT of post-obese subjects is most likely not an indicator for inflammation, but rather an indicator for increased lipolysis and adipose tissue catabolism. Notably, after bariatric surgery SAT gene expression reflects a cachexia-like phenotype and differs from the lean state.

Statistik
Das PDF-Dokument wurde 1 mal heruntergeladen.
Lizenz
CC-BY-Lizenz (4.0)Creative Commons Namensnennung 4.0 International Lizenz