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Titel
A 5year update of patients with HPV positive versus negative oropharyngeal cancer after radiochemotherapy in Austria
Verfasser / VerfasserinLill, Claudia ; Bachtiary, Barbara ; Selzer, Edgar ; Mittlboeck, Martina ; Thurnher, Dietmar
Erschienen in
Wiener klinische Wochenschrift, 2017, Jg. 129, H. 11-12, S. 398-403
ErschienenSpringer, 2017
SpracheEnglisch
DokumenttypAufsatz in einer Zeitschrift
Schlagwörter (EN)Oropharyngeal cancer / Human papilloma virus / Radiochemotherapy / Update
URNurn:nbn:at:at-ubmuw:3-3481 Persistent Identifier (URN)
DOI10.1007/s00508-017-1171-5 
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 Das Werk ist frei verfügbar
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A 5year update of patients with HPV positive versus negative oropharyngeal cancer after radiochemotherapy in Austria [0.34 mb]
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Zusammenfassung (Englisch)

Background

After publishing promising results for the treatment of patients with human papilloma virus (HPV) positive oropharyngeal cancer with radiochemotherapy regarding 2year survival, we present an update of the disease-specific and disease-free survival after 5 years.

Patients and methods

A total of 29 patients of which 18 were HPV negative and 11 HPV positive with squamous cell carcinoma of the oropharynx received radiation therapy with or without chemotherapy (cisplatin) or immunotherapy (cetuximab) between 2007 and 2009. At time of the present analysis, six patients are still alive including four with HPV positive and two with HPV negative oropharyngeal carcinoma, while 15 out of 16 patients with HPV negative tumors died and 1 died of another cause with evidence of disease.

Results

Since the 2year disease-specific survival of patients with HPV positive cancer of the oropharynx was published with 100% versus 30.4% in HPV negative tumors, we now present the 5year disease-specific survival after treatment, which was 85.7% in HPV positive versus 11.1% in HPV negative patients.

Conclusion

We present the results of patients receiving radiochemo(immuno)therapy for oropharyngeal cancer regarding the HPV status, which is still promising.

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CC-BY-Lizenz (4.0)Creative Commons Namensnennung 4.0 International Lizenz