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Prognostic role of expression of N-cadherin in patients with upper tract urothelial carcinoma : a multi-institutional study
Verfasser / VerfasserinShariat, Shahrokh F. ; Abufaraj, Mohammad ; Moschino, Marco ; Soria, Francesco ; Gust, Kilian ; Özsoy, Mehmet ; Mathieu, Romain ; Roupret, Morgan ; Margulis, Vitaly ; Karam, Jose A. ; Wood, Christopher G. ; Briganti, Alberto ; Bensalah, Karim ; Haitel, Andrea
Erschienen in
World Journal of Urology, 2017, Jg. 35, H. 7, S. 1073-1080
ErschienenSpringer, 2017
SpracheEnglisch
DokumenttypAufsatz in einer Zeitschrift
Schlagwörter (EN)N-Cadherin / Urothelial carcinoma / Upper tract urothelial carcinoma / UTUC prognosis / Survival / Prediction
URNurn:nbn:at:at-ubmuw:3-3533 Persistent Identifier (URN)
DOI10.1007/s00345-016-1968-2 
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Prognostic role of expression of N-cadherin in patients with upper tract urothelial carcinoma [1.18 mb]
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Zusammenfassung (Englisch)

Purpose

To assess the role of N-cadherin as prognostic biomarker in patients with upper tract urothelial carcinoma (UTUC) in a large multi-institutional cohort of patients.

Patients and methods

Immunohistochemistry was used to evaluate the status of N-cadherin expression in 678 patients with unilateral sporadic UTUC treated with radical nephroureterectomy. N-cadherin was considered positive if any immunoreactivity with membranous staining was detected. The KaplanMeier method was used to estimate recurrence-free survival, overall survival and cancer-specific survival. Disease recurrence, overall mortality and cancer-specific mortality probabilities were tested in Cox regression models.

Results

Expression of N-cadherin was observed in 292 (43.1%) of patients, and it was associated with advanced tumour stage (p < 0.04), lymph node metastases (p = 0.04) and sessile architecture (p < 0.02). Within a median follow-up of 37.5 months (IQR 2066), 171 patients (25.2%) experienced disease recurrence and 150 (22.1%) died from UTUC. In univariable analyses, N-cadherin expression was significantly associated with higher probability of recurrence (p = 0.01), but not overall (p = 0.9) or cancer-specific mortality (p = 0.06). When adjusted for the effects of all available confounders, N-cadherin was not associated with any of the survival outcomes.

Conclusion

N-cadherin is expressed in approximately 2/5 of UTUs. It is associated with adverse pathologic factors but not with survival outcomes. Its clinical value remains limited.

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CC-BY-Lizenz (4.0)Creative Commons Namensnennung 4.0 International Lizenz